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Synthesis of 1,2,3,4-tetrahydropyrido- [2,3-b]pyrazine-2,3-dione derivatives with a chiral substituent at the nitrogen atomстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Kurkin A.V., Bukhryakov K.V., Yurovskaya M.A.
- Журнал: Chemistry of Heterocyclic Compounds
- Том: 45
- Номер: 2
- Год издания: 2009
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 188
- Последняя страница: 193
- DOI: 10.1007/s10593-009-0249-z
- Аннотация: The sequence of steps including nucleophilic substitution of the chlorine atom in 2-chloro-3-nitropyridine by esters of optically active phenylalanine, reduction of the nitro group, acylation with ethyl oxalyl chloride, and intramolecular cyclization, leads to the synthesis of derivatives of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-2,3-dione with a chiral substituent at the nitrogen atom. It was established that, depending on the conditions of carrying out the cyclization, the parallel formation of derivatives of imidazo[4,5-b]pyridine is possible. Conditions were found for selectively carrying out the cyclization under with only structures of pyrazines or imidazole condensed with pyridine were formed. © 2009 Springer Science+Business Media, Inc.
- Добавил в систему: Юровская Марина Абрамовна