Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridines

Paronikyan, E.G.; Dashyan, S.S.; Dzhagatspanyan, I.A.; Paronikyan, R.G.; Nazaryan, I.M.; Akopyan, A.G.; Minasyan, N.S.; Ayvazyan, A.G.; Tamazyan, R.A.; Babaev, E.V.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 июня 2016 г.

Авторы: Paronikyan E.G., Dashyan Sh Sh, Dzhagatspanyan I.A., Paronikyan R.G., Nazaryan I.M., Akopyan A.G., Minasyan N.S., Ayvazyan A.G., Tamazyan R.A., Babaev E.V.
Журнал: Russian Journal of Bioorganic Chemistry
Том: 42
Номер: 2
Год издания: 2016
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 215
Последняя страница: 223
DOI: 10.1134/S1068162016020102
Аннотация: New diamino derivatives of pyrano[3,4-c]pyridines were synthesized by the pyridine ring recyclization. The presence of the intramolecular hydrogen bond in 6-[(4-methoxyphenyl)amino]-3,3-dimethyl8-methylamino-3,4-dihydro-1H-pyrano[3,4-c]pyridin-5-carbonitrile was identified by X-ray diffraction. A pharmacological study of the synthesized compounds was carried out in known tests, such as assay for antagonism induced by corazole subcutaneous injection and the open field test. The method of rotating rod was used to evaluate neurotoxicity. The diamino derivatives of pyrano[3,4-c]pyridines were found to possess neutrotropic properties. The synthesized compounds, as well as diazepam, prevent the occurrence of clonic seizures and clonic corazoleinduced convulsions in animals; however, they cause a behavior-depressing sedative effect.
Добавил в систему: Бабаев Евгений Вениаминович

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Synthesis and neurotropic activity of 6,8-diamino derivatives of pyrano[3,4-c]pyridinesстатья

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