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Cytotoxicity Screening of hot-water extracts of Agaricomycetes mushroomsтезисы доклада
- Авторы: Shnyreva AV, Mukhina VS, Svirshevskaja EV
- Сборник: Abstracts of the 18th Сongress of the International Society for Mushroom Science
- Тезисы
- Год издания: 2012
- Место издания: China Agriculture Press China, Beijing
- Первая страница: 171
- Аннотация: Polysaccharides of some basidiomycete fungi are known to be effective immunomodulators and potential antitumor agents. Majority of research papers discusses their role as immunomodulators, but only a few reports studied the ability of mushroom hot water extracts to affect tumor cells directly. In this study we evaluated cytotoxicity of hot water extracts isolated from different Agaricomycetes mushrooms with the aim to investigate a possible mechanism of their action. Cytotoxicity was measured on Jurkat, K562, HEK-T, THP-1, HBL cell lines by MTT-assay. Pro-apoptotic activity and the ability of mushroom extracts to arrest the cell cycle were observed by flow cytometry.
- Добавил в систему: Шнырева Алла Викторовна