|
ИСТИНА |
Войти в систему Регистрация |
ФНКЦ РР |
||
Dissection of chromatin features in the 4q35 chromosomal region in facioscapulohumeral dystrophy myoblasts and cervical carcinoma cellsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 мая 2016 г.
- Авторы: Kisseljova N.P., Dmitriev P., Katargin A., Kim E., Ezerina D., Markozashvili D., Malysheva D., Planche E., Lemmers R.J.L.F, van_der_Maarel S.M., Laoudj-Chenivesse D., Lipinski M., VASSETZKY Y.S.
- Журнал: European Journal of Human Genetics
- Том: 22
- Год издания: 2014
- Издательство: Nature Publishing Group
- Местоположение издательства: United Kingdom
- Первая страница: 1117
- Последняя страница: 1123
- DOI: 10.1038/ejhg.2013.306
- Аннотация: Mechanisms that regulate attachment of the scaffold/matrix attachment regions (S/MARs) to the nuclear matrix remain largely unknown. We have studied the effect of simple sequence length polymorphism (SSLP), DNA methylation and chromatin organization in an S/MAR implicated in facioscapulohumeral dystrophy (FSHD), a hereditary disease linked to a partial deletion of the D4Z4 repeat array on chromosome 4q. This FSHD-related nuclear matrix attachment region (FR-MAR) loses its efficiency in myoblasts from FSHD patients. Three criteria were found to be important for high-affinity interaction between the FR-MAR and the nuclear matrix: the presence of a specific SSLP haplotype in chromosomal DNA, the methylation of one specific CpG within the FR-MAR and the absence of histone H3 acetylated on lysine 9 in the relevant chromatin fragment.
- Добавил в систему: Васецкий Егор Сергеевич