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History of chromosome rearrangements reflects the spatial organization of yeast chromosomesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 июля 2016 г.
- Авторы: Khrameeva E.E., Fudenberg G., Gelfand M.S., Mirny L.A.
- Журнал: Journal of Bioinformatics and Computational Biology
- Том: 14
- Номер: 2
- Год издания: 2016
- Издательство: Imperial College Press
- Местоположение издательства: United Kingdom
- Первая страница: 1641002
- DOI: 10.1142/S021972001641002X
- Аннотация: Three-dimensional (3D) organization of genomes affects critical cellular processes such as transcription, replication, and deoxyribo nucleic acid (DNA) repair. While previous studies have investigated the natural role, the 3D organization plays in limiting a possible set of genomic rearrangements following DNA repair, the influence of specific organizational principles on this process, particularly over longer evolutionary time scales, remains relatively unexplored. In budding yeast S.cerevisiae, chromosomes are organized into a Rabl-like configuration, with clustered centromeres and telomeres tethered to the nuclear periphery. Hi-C data for S.cerevisiae show that a consequence of this Rabl-like organization is that regions equally distant from centromeres are more frequently in contact with each other, between arms of both the same and different chromosomes. Here, we detect rearrangement events in Saccharomyces species using an automatic approach, and observe increased rearrangement frequency between regions with higher contact frequencies. Together, our results underscore how specific principles of 3D chromosomal organization can influence evolutionary events.
- Добавил в систему: Рогаев Евгений Иванович