Audiogenic epilepsy - The pathological neural net and genetic predispositionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 23 сентября 2013 г.
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Авторы:
Fedotova I.,
Surina N.,
Pospelov A.,
Poletaeva I.
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Журнал:
Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
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Год издания:
2012
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Первая страница:
747
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Последняя страница:
749
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DOI:
10.1109/iCBEB.2012.87
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Аннотация:
The paper is the minireview of the main data concerning the functional properties of rodent audiogenic epilepsy (AE) in rats of inbred strain Krushinsky-Molodkina - KM (Moscow, Russia). These data demonstrate that the genetically determined abnormal functions of CNS (presumably in brainstem neural circuits) which are the cause of AE could be responsible not only for the clonic and tonic seizures in response to loud sound but for the postictal cataleptic state as well. After AE seizure fit the brain stem acoustic evoked potentials changes, probably due to inactivation of inferior colliculi. AE is the valuable model for the preclinical investigation of new pharmacological agents and for study the intrinsic mechanisms of the epileptogenesis. © 2012 IEEE.
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Добавил в систему:
Федотова Ирина Борисовна