Laboratory rat selection for the trait "the absence of audiogenic seizure proneness"статья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Авторы:
Fedotova I.B. ,
Kostina Z.A. ,
Surina N.M. ,
Poletaeva I.I.
Журнал:
Russian Journal of Genetics
Том:
48
Номер:
6
Год издания:
2012
Издательство:
Maik Nauka/Interperiodica Publishing
Местоположение издательства:
Russian Federation
Первая страница:
581
Последняя страница:
586
DOI:
10.1134/S1022795412040059
Аннотация:
The hybrids between Krushinsky-Molodkina (KM) inbred strain, selected for high predisposition to audiogenic epilepsy (AE), and Wistar rats non-prone to audiogenic seizure were the initial population for selection. Rats were selected for the trait "the absence of audiogenic seizure proneness". The creation of such strain in which the significant proportion of animals develop no AE in response to sound and share partly the genetic background of the KM strain is very important for the correct use of KM strain as the laboratory model of seizure states. As alleles which determine the AE proneness are recessive the selection for the "opposite" trait proceeds necessarily slow. © 2012 Pleiades Publishing, Ltd.
Добавил в систему:
Федотова Ирина Борисовна