TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Diseaseстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 июля 2019 г.
Аннотация:M.J. Haney, N.L. Klyachko, E.B. Harrison, Y. Zhao, A.V. Kabanov, E.V. Batrakova (2019). TTP1 Loaded Exosomes for Enzyme Lysosomal Delivery and Enhanced Exosomes Distribution to the Brain in the Animal Model of Batten Disease. Adv. Healthcare Mater 2019. V. 8. Iss. 11. e1801271 (2019-Apr-18). P. 1-12 (published Jun 6).
ISSN: 2192-2659
DOI:10.1002/adhm.201801271
IF 5.609 (Q1)
RFBR grants 17-54-33027, 18-29-09154
The development and validation of extracellular vesicle (EV)‐based drug delivery system for the treatment of lysosomal storage diseases are the focus of this manuscript. EVs are loaded with therapeutic protein, TPP1, through transfection of parental cells, macrophages, or incorporation of TPP1 into naïve EVs. Systemic administration of EV‐TPP1 increases lifespan and decreases neuroinflammation in LINCL mice