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The effect of lamotrigine and carbamazepine on the development of the audiogenic seizure reaction in rats of the Krushinskii-Molodkina strainстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
- Авторы: Fedotova I.B., Semiokhina A.F., Kosacheva E.S., Bashkatova V.G., Raevskii K.S.
- Журнал: Eksperimental’naia i klinicheskaia farmakologiia
- Том: 59
- Номер: 6
- Год издания: 1996
- Первая страница: 6
- Последняя страница: 9
- Аннотация: The effect of Lamotrigine and carbamazepine on the development and character of the epileptiform seizures after strong sonic stimulation were studied on Krushinskii-Molodkina line of rats. Both drugs manifested a dose-dependent increase in the latency of motor reaction Lamotrigine administration in the dose range of 5-40 mg/kg, i.p., resulted in a moderate decrease in the seizure intensity preventing predominantly the tonic component of the seizure and failed to modify the character of convulsive reaction. Carbamazepine administered in doses of 7.5-30 mg/kg effectively prevented the epileptiform seizures. The "two-wave" motor reaction was observed in 15% of carbamazepine-treated rats.
- Добавил в систему: Федотова Ирина Борисовна