New method of preparation of C(2)F(5)Li and its reactions with cyclic imines and lactims: Synthesis of alpha-pentafluoroethyl prolineстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:Addition of pentafluoroethyllithium to cyclic imines leads to pentafluoroethyl substituted pyrrolidines, piperidines and azepanes while reaction of cyclic lactims gives rise to 2-pentafluoroethyl imines. Oxidative cleavage of 2-furyl-2-pentafluoroethyl pyrrolidine has been found to be an effective method for the preparation of a racemic alpha-pentafluoroethyl proline. (c) 2008 Elsevier B.V. All rights reserved.