Search for Associations between G/A Polymorphism of the EPAS1 Gene and the Maximal Oxygen Consumption in Russian Athletes

Bondareva, E.A.; Bleer, A.N.; Godina, E.Z.

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 28 октября 2016 г.

Авторы: Bondareva E.A., Bleer A.N., Godina E.Z.
Журнал: Human Physiology
Том: 42
Номер: 3
Год издания: 2016
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 335
Последняя страница: 338
DOI: 10.1134/S0362119716010047
Аннотация: Abstract—This study investigates associations between G/A polymorphism of the epithelial PAS domain protein 1 (EPAS1) gene (rs1867785) and the maximum rate of oxygen consumption (VO2max) in male Russianathletes. The study engaged 241 male athletes from different sports; the control group of nonathletes included92 subjects. Increased frequencies of the AA and AG genotypes of the EPAS1 gene (χ2 = 14.16, p = 0.03) werefound in the cohort of male athletes. The frequencies of these alleles in the subgroups with moderate(EPAS1*A 38.1% and EPAS1*G 61.9%) and high (EPAS1*A 41.8% and EPAS1*G 58.2%) VO2max values significantly differed from those in the control group (χ2 = 7.53, p = 0.006 and χ2 = 6.58, p = 0.01, respectively).The higher aerobic capacities are probably associated with the presence of at least one minor A allele of theEPAS1 gene in the genome.Keywords: genetics of sports, EPAS1, maximal oxygen consumption, athletes, athlete selection
Добавил в систему: Бондарева Эльвира Александровна

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Search for Associations between G/A Polymorphism of the EPAS1 Gene and the Maximal Oxygen Consumption in Russian Athletesстатья

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