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New poly(3-hydroxybutyrate)-based systems for controlled release of dipyridamole and indomethacinстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Bonartsev A.P., Bonartseva G.A., Makhina T.K., Myshkina V.L., Luchinina E.S., Livshits V.A., Boskhomdzhiev A.P., Markin V.S., Iordanskii A.L.
- Журнал: Applied Biochemistry and Microbiology
- Том: 42
- Номер: 6
- Год издания: 2006
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 625
- Последняя страница: 630
- DOI: 10.1134/S0003683806060159
- Аннотация: New poly-(3-hydroxybutyrate)-based systems for controlled release of anti-inflammatory and antithrombogenic drugs have been studied. The release occurs via two mechanisms (diffusion and degradation) operating simultaneously. Dipyridamole and indomethacin diffusion processes determine the rate of the release at the early stages of the contact of the system with the environment (the first 6–8 h). The coefficient of the release diffusion of a drug depends on its nature, the thickness of the poly-(3-hydroxybutyrate) films containing the drug, the concentrations of dipyridamole and indomethacin, and the molecular weight of the poly-(3- hydroxybutyrate). The results obtained are critical for developing systems of release of diverse drugs, thus, enabling the attainment of the requisite physiological effects on tissues and organs of humans
- Добавил в систему: Бонарцев Антон Павлович