|
ИСТИНА |
Войти в систему Регистрация |
ФНКЦ РР |
||
Antiproliferative potential of 3β,5α,6β,7αtetrahydroxyergosta-8(14),22-diene produced by Acremonium persicinum isolated from an alkalinecrater lake in Puebla, Mexicoстатья
- Авторы: Franceschy C., Espinoza C., Padrón JM, Landa-Cadena G., Norte M., Fernández JJ, Shnyreva AV, Trigos A.
- Журнал: Natural Product Research
- Том: 35
- Номер: 17
- Год издания: 2019
- Издательство: Taylor & Francis
- Местоположение издательства: United Kingdom
- Первая страница: 2895
- Последняя страница: 2898
- DOI: 10.1080/14786419.2019.1669032
- Аннотация: The sterol 3β,5α,6β,7α-tetrahydroxyergosta-8(14),22-diene was obtained from bio-guided fractioning of the chloroform extract of 50 L of liquid culture of Acremonium persicinum. This fungal strain was selected because of its anti-proliferative activity against solid human tumor cell lines (GI50 ≤ 50 μg/mL) in a bio-prospective study of fungi isolated from plant material, sediment and water samples obtained from alkaline lakes Alchichica and Atexcac in Puebla, Mexico. This compound showed GI50 (μM) values of: 16, 24, 18, 15 and 12 against tumor cell lines A-549, HBL-100, HeLa, T-47D and WiDr respectively. GI50 effects against tumor lines T-47D and WiDr were found to be greater than the clinically used drugs Etoposide and Cisplatin.
- Добавил в систему: Шнырева Алла Викторовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Nat_Product_Res_2019.pdf | 686,0 КБ | 23 октября 2019 [Shnyreva_Alla] | |
| 2. | Полный текст | gnpl_a_1669032_sm3577.pdf | 791,1 КБ | 23 октября 2019 [Shnyreva_Alla] |