Time-resolved Monte Carlo simulation of photon migration in tissue phantom in relation to glucose sensing

Авторы: Popov A., Priezzhev A., Myllylä R.
Сборник: ICONO 2005: Nonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry
Серия: Proc. SPIE
Том: 6257
Год издания: 2006
Издательство: SPIE
Местоположение издательства: Bellingham, WA, United States
Первая страница: 62570Y
DOI: 10.1117/12.678392
Аннотация: Glucose sensing is of great importance nowadays. In this paper, we apply the Monte Carlo technique to simulate the effect of glucose on pulse propagation within a 4% Intralipid skin phantom. This effect is based on refractive index matching of Intralipid vesicles relative to surrounding liquid (water) if glucose is added. Time-of-flight profiles of femtosecond pulses (906 nm) passed through a 2-mm thick plain glass cuvette are registered by two detectors 0.3 mm in diameter with numerical apertures of 0.19 and 0.29. It is found that glucose levels within the physiological range (100-500 mg/dl) and 1000 mg/dl can be detected due to the effect of glucose on peak location and intensity, and width of the registered pulses.
Добавил в систему: Приезжев Александр Васильевич

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