Аннотация:In the ascomycete fungus Neurospora crassa blue-violet light controls the expression of genes responsible for differentiation
of reproductive structures, synthesis of secondary metabolites, and the circadian oscillator activity. A major photoreceptor in
Neurospora cells is WCC, a heterodimeric complex formed by the PAS-domain-containing polypeptides WC-1 and WC-2, the
products of genes white collar-1 and white collar-2. The photosignal transduction is started by photochemical activity of an excited
FAD molecule noncovalently bound by the LOV domain (a specialized variant of the PAS domain). The presence of zinc fingers
(the GATA-recognizing sequences) in both WC-1 and WC-2 proteins suggests that they might function as transcription factors.
However, a critical analysis of the phototransduction mechanism considers the existence of residual light responses upon absence
of WCC or its homologs in fungi. The data presented point at endogenous ROS generated by a photon stimulus as an alternative
input to pass on light signals to downstream targets.