Model of membrane fusion: Continuous transition to fusion pore with regard of hydrophobic and hydration interactionsстатья
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Дата последнего поиска статьи во внешних источниках: 4 декабря 2016 г.
Авторы:
Akimov S.A. ,
Molotkovsky R.J. ,
Galimzyanov T.R. ,
Radaev A.V. ,
Shilova L.A. ,
Kuzmin P.I. ,
Batishchev O.V. ,
Voronina G.F. ,
Chizmadzhev Yu A.
Журнал:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology
Том:
8
Номер:
2
Год издания:
2014
Издательство:
Pleiades Publishing, Ltd
Местоположение издательства:
Road Town, United Kingdom
Первая страница:
153
Последняя страница:
161
Оригинальные версии:
Модель слияния мембран: непрерывный переход в пору слияния с учетом гидрофобных и гидратационных взаимодействий
DOI:
10.1134/S1990747814010024
Аннотация:
We consider the process of fusion of lipid membranes from the stage of stalk with minimal radius to the stage of fusion pore. We assume that stalk directly developed into the fusion pore, omitting the stage of hemifusion diaphragm. Energy of intermediate stages is calculated on the basis of the classical elasticity theory of liquid crystals adapted for lipid membranes. The trajectory of transition from stalk to pore is obtained with regard to hydrophobic and hydration interactions. Continuous change of orientation of lipids in distal monolayers occurs along the trajectory. The orientation changes from the direction along rotational axis of the system specific to stalk to the direction corresponding to the fusion pore. Dependence of energy of intermediate stages on the value of spontaneous curvature of distal monolayers of the fusing membranes is obtained. We demonstrate that the energy barrier of the stalk-to-pore transition decreases when distal monolayers have positive spontaneous curvature, which is in accordance with available experimental data. © 2014 Pleiades Publishing, Ltd.
Добавил в систему:
Рубин Андрей Борисович