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Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampusстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 ноября 2019 г.
- Авторы: Encinas Juan M., Michurina Tatyana V., Peunova Natalia, Park June-Hee, Tordo Julie, Peterson Daniel A., Fishell Gord, Koulakov Alex, Enikolopov Grigori
- Журнал: Cell Stem Cell
- Том: 8
- Номер: 5
- Год издания: 2011
- Издательство: Cell Press
- Местоположение издательства: United States
- Первая страница: 566
- Последняя страница: 579
- DOI: 10.1016/j.stem.2011.03.010
- Аннотация: Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous depletion of the neural stem cell pool, as a consequence of their division, may contribute to the age-related decrease in hippocampal neurogenesis. Our results indicate that adult hippocampal stem cells, upon exiting their quiescent state, rapidly undergo a series of asymmetric divisions to produce dividing progeny destined to become neurons and subsequently convert into mature astrocytes. Thus, the decrease in the number of neural stem cells is a division-coupled process and is directly related to their production of new neurons. We present a scheme of the neurogenesis cascade in the adult hippocampus that includes a proposed “disposable stem cell” model and accounts for the disappearance of hippocampal neural stem cells, the appearance of new astrocytes, and the age-related decline in the production of new neurons.
- Добавил в систему: Ениколопов Григорий Николаевич