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Lateralized differences in pallidal excitation/inhibition balance in patients with cervical dystoniaтезисы доклада
- Авторы: Semenova U., Tomskiy A., Popov V., Shaikh A.G., Sedov A.
- Сборник: Abstract book of XIIIth IBAGS Meeting, April 28 - May 2, 2019, Biarritz, France
- Тезисы
- Год издания: 2019
- Место издания: International Basal Ganglia Society
- Первая страница: 153
- Последняя страница: 153
- Аннотация: Lateralized differences in pallidal outflow is assumed to be linked with asymmetric pathological tension of the neck muscles in cervical dystonia (CD) patients. At the population level the interhemispheric asymmetry was usually studied regarding the estimation of the spectral power in specified frequency bands, without taking in consideration the broadband spectral features. Nowadays, it was showed that the 1/f broadband activity is a neurophysiological indicator of excitation/inhibition ratio (Gao et al., 2017). In view of these concerns, we recorded pallidal LFPs bilaterally in seven CD patients with combined latero- and torticollis and examined how lateralized asymmetry impacts on the 1/f broadband activity. LFPs was recorded intraoperatively during DBS surgery. All patients showed a trend towards an asymmetric difference in the 1/f broadband activity. Ipsilateral 1/f slope was greater in both GPi and GPe than contralateral, along with the prominent correlation between GPi and GPe slopes. We found that torticollis and the interaction between torti- and laterocollis had a strong impact on the 1/f broadband asymmetry, while only laterocollis had almost no significant influence. Our findings emphasize the importance of mainstreaming a broadband activity in the estimation of LFP spectral features and provide further evidence for the pallidal asymmetry in CD patients. This study was supported by Russian Foundation for Basic Research (RFBR) (18- 315-00202) Keywords: dystonia, LFP, globus pallidus 1) Gao, R., Peterson, E.J., Voytek, B., 2017. Inferring synaptic excitation/inhibition balance from field potentials. NeuroImage 158, 70–78
- Добавил в систему: Гамалея Анна Александровна