Decarboxylation and electrophilic substitution in 3-tert-butyl-4-oxopyrazolo[5,1-c][1,2,4]triazinesстатья
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Дата последнего поиска статьи во внешних источниках: 8 декабря 2019 г.
Аннотация:Reactivity of 7-R-3-tert-butyl-4-oxo-4,6-dihydropyrazolo[5,1-c][1,2,4]triazine-8-carboxylic acids (R = NH2, N-3, H) and products of their decarboxylation towards different electrophilic agents (chloroacetone, Boc(2)O/NaN3, DMF/POCl3, TMSBr, N-halosuccinimides, and HNO2) was studied. A selective synthesis of new C(7),C(8)-functionalized and N(1)-tert-butyloxycarbonyl-substituted 4-oxopyrazolo[5,1-c][1,2,4]triazines was performed. The structures of the synthesized compounds were confirmed by IR and NMR spectroscopy, high resolution mass spectrometry and single crystal X-ray diffraction analysis.