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An attenuated variant of the GDVII strain of Theiler's virus does not persist and does not infect the white matter of the central nervous systemстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Jarousse N., Viktorova E.G., Pilipenko E.V., Agol V.I., Brahic M.
- Журнал: Journal of Virology
- Том: 73
- Номер: 1
- Год издания: 1999
- Издательство: American Society for Microbiology
- Местоположение издательства: United States
- Первая страница: 801
- Последняя страница: 804
- Аннотация: The DA strain of Theiler's virus causes a persistent and demyelinating infection of the white matter of spinal cord, whereas the GDVII strain causes a fatal gray-matter encephalomyelitis. Studies with recombinant viruses showed that this difference in phenotype is controlled mainly by the capsid. However, conflicting results regarding the existence of determinants of persistence in the capsid of the GDVII strain have been published. Here we show that a GDVII virus whose neurovirulence has been attenuated by an insertion in the 5' noncoding region does not persist in the central nervous systems of mice. Furthermore, this virus infects the gray matter efficiently, but not the white matter. These results confirm the absence of determinants of persistence in the GDVII capsid. They suggest that the DA capsid controls persistence by allowing the virus to infect cells in the white matter of the spinal cord.
- Добавил в систему: Агол Вадим Израилевич