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Rat liver epigenome programing by perinatal exposure to 2,2′,4′4′-tetrabromodiphenyl etherстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Alexander Suvorov, Vladimir Naumov, Victoria Shtratnikova, Maria Logacheva, Alex Shershebnev, Haotian Wu, Evgeny Gerasimov, Anna Zheludkevich, Pilsner Jonathan R., Oleg Sergeyev
- Журнал: Epigenomics
- Год издания: 2019
- Издательство: Future Medicine Ltd.
- Местоположение издательства: United Kingdom
- DOI: 10.2217/epi-2019-0315
- Аннотация: Perinatal exposures to polybrominated diphenyl ethers permanently reprogram liver metabolism and induce a nonalcoholic fatty liver disease-like phenotype and insulin resistance in rodents. Aim: To test if these changes are associated with altered liver epigenome. Materials & methods: Expression of small RNA and changes in DNA methylation in livers of adult rats were analyzed following perinatal exposure to 2,2′,4,4′-tetrabromodiphenyl ether, the polybrominated diphenyl ether congener most prevalent in human tissues. Results: We identified 33 differentially methylated DNA regions and 15 differentially expressed miRNAs. These changes were enriched for terms related to lipid and carbohydrate metabolism, insulin signaling, Type-2 diabetes and nonalcoholic fatty liver disease. Conclusion: Changes in the liver epigenome are a likely candidate mechanism of long-term maintenance of an aberrant metabolic phenotype.
- Добавил в систему: Штратникова Виктория Юрьевна