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Subthreshold Corazol Doses Induced Generalized Seizures in Audigenic Seizure-Prone Ratsстатья
- Авторы: Fedotova Irina B., Surina Natalia M., Nikolaev Georgy M., Poletaeva Inga I.
- Журнал: International Journal of Neurology and Brain Disorders
- Том: 3
- Номер: 3
- Год издания: 2016
- Первая страница: 1
- Последняя страница: 6
- DOI: 10.15436/2377-1348.16.954
- Аннотация: It was suggested that high audiogenic epilepsy (AE) susceptibility in rats of Krushinsky-Molodkina (KM) rat strain could be accompanied by increase in general seizure proneness. This could be tested exploring the reaction to low corazol doses in these rats and in rats of genetically related but non-prone to AE strain (strain “0”), which was used as control. 6 months old male rats of two strains (KM and received the subthreshold (40 mg/kg) corazol injections. After injections rats were placed in individual cages and were observed for 40 - 50 min in order to discover the display/absence of corazol induced convulsions. Results: The typical corazol seizures developed in more than 50% of KM rats (AE-susceptible) in comparison to non-prone control rats, in which these seizures were more rare events. The control rats of “0” strain demonstrated seizures of significantly lower intensity,than in KM rats. Although most rats of “0”, which did not express corazol seizures and no AE seizures three weeks before the experiment as well, they demonstrated the intense AE seizures when tested 20 min after corazol injection. I.e., rats of KM strain, for intense AE seizures, developed generalized seizures in response to subthreshold corazol dose, demonstrating the elevated general seizure proneness.
- Добавил в систему: Лильп Ирина Германовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | corazol-printed.pdf | 470,0 КБ | 25 августа 2016 [irinalilp] |