Frustration Tolerance and Glucocorticoid Activeness in Patients with Mitral Valve Prolapse and Autonomic DysfunctionстатьяТезисы
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Дата последнего поиска статьи во внешних источниках: 8 января 2017 г.
Аннотация:Background.
Urgency of psychophysiological examination of MVP patients is suggested by the risk of development of serious complications, induced by the disease; the most perilous complication is sudden death at a young age, inspired mostly by emotional and physical loads.
Present research aims to study frustration tolerance and its correlation with glucocorticoid function activity in MVP patients with autonomic dysfunction (AD).
Methods.
Frustration tolerance was undertaken with our modified version of Rosenzweig Picture-Frustration Test (Zinchenko, Pervichko, 2014; Pervichko, Zinchenko, 2016). The trait anxiety level (TA) was assessed with the State-Trait Anxiety Inventory (Spielberger, 1989). A revised version of Eysenck Personality Questionnaire (EPQ-R) was employed to study personality traits.
The cortisol level in blood plasma was measured by radioimmunoassay technique with radioimmune assay kit of cortisol in human blood plasma ‘KORT-3N’ (Belarus).
There were 32 MVP patients (mean age was 28.5±1.6 years) and 15 healthy people (mean age was 27.5±1.3 years) who took part in the study.
Results.
MVP patients significantly more frequently (p<0.001) would mark Rosenzweig's situations as potentially traumatizing: 11.2±1.8 vs 5.8±1.3. Among reactions to frustration revealed by MVP patients the following categories are dominating: extrapunitive (Е) (46.0% vs 36.8%, p<0.01), ego-defensive (ED) (41.5% vs 35.9%, p<0.05), and obstacle-dominance (OD) (34.2% vs 25.6%, p<0.01). That is, the subject’s answers focus on the traumatic character of the situation and make an external cause the culprit of frustration, they address their animosity ad extra. There was revealed a direct correlation between TA indexes and E, ED – reactions: TA and Е (r = 0.49, р<0.001); TA and ED (r = 0.46, р<0.01). Another direct correlation was established between TA indexes and indexes of AD (r = 0.43, р<0.01).
There was displayed a higher level of cortisol in MVP patients with severe grade of AD, against the level revealed by patients with average grade of AD (433.9±78.0 mmol/l vs 299.3±42.9 mmol/l; p<0.05). Direct correlations were established between the cortisol level and the level of TA (r=0.45; р<0.01); between the level of neuroticism and the cortisol level (r=0.43; p<0.05); between the frequency of E-reactions in Rosenzweig Test and cortisol level (r=0.42; р<0.01).
Discussion.
Obtained results testify to reduction of frustration tolerance and derangement of emotion regulation in MVP patients, and overreaction to stress by the time of examination.
Conclusion.
Along with low frustration tolerance, registered AD, high level of TA and neuroticism, MVP patients reveal higher indexes of cortisol in blood plasma.