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RELATIONSHIP BETWEEN CORTEX AND AUTONOMIC NERVOUS SYSTEM BY MENTAL ACTIVITY IN PATIENTS WITH MILD COGNITIVE IMPAIREMENTтезисы доклада
- Авторы: Fokin V., Ponomareva N., Medvedev R., Lagoda O.Tanashian M
- Сборник: The 2016 Alzheimer’s disease congress, London, UK
- Тезисы
- Год издания: 2016
- Место издания: London, UK
- Первая страница: 42
- Последняя страница: 42
- Аннотация: Mental activity is accompanied by the activation of the autonomic nervous system (ANS), and may cause mental stress and pronounced changes in brain energy metabolism in patients with mild cognitive impairment (MCI). 132 MCI patients, men and women, were examined during the performance of cognitive tests: proofreading, verbal fluency and verbal memory Luria test. Blood pressure, heart rate, Doppler measure of linear blood flow velocity (LBV) in cerebral arteries, DC potentials of the brain were recorded. Glucose in blood, cortisol and insulin in saliva were examined before and after the performance of cognitive tests. During the performance of cognitive tests significant increase in blood pressure and heart rate, as well as the DC potentials in different area of the head was observed. After the tests the level of glucose showed a decrease (-0.68+/-0.2 mmol/l), and the concentration of cortisol and insulin showed a significant increase (11.6+/-3.3 nmol/l; 4.7+/-1.2 pmol/l). Lowering of blood glucose level was associated with worse performance of the proofreading test (r=0.44, p=0.001) and better performance of verbal fluency test (r=0.28, p=0.04). Better performance of verbal fluency test correlated with the increasing of heart rate during the test (r=0.41; p=0.001). The increase of DC potential in left temporal area was associated with better verbal memory in Luria’s test (F=6.9, p=0.01). LVB in the main cerebral arteries of the head was not significantly changed during cognitive tasks. However the increase of LVB during the test in right middle cerebral artery was associated with worse performance of proofreading test (F=6.6; p=0.02). The results suggest that the performance of different cognitive tests is accompanied by similar pattern of ANS reactivity. However successful performance of cognitive tests correlated with different characteristics of ANS reactivity, this may be due to the activation of different cortical and ANS structures during cognitive processing.
- Добавил в систему: Фокин Виталий Федорович