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[Introduction of biologically active fragments of interferon-alpha2 and insulin into the artificial protein albebetin affects immunogenicity of the final construct]статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Bocharova O.V., Moshkovski? S.A., Chertikova R.V., Abdullaev Z.K.h, Kolesanova E.F., Dolgikh D.A., Kirpichnikov M.P.
- Журнал: Voprosy medit∎sinsko∎ khimii
- Том: 48
- Номер: 1
- Год издания: 2002
- Издательство: Rossi∎skai∎a akademii∎a medit∎sinskikh nauk
- Местоположение издательства: Moskva, Russia (Federation)
- Первая страница: 94
- Последняя страница: 102
- Аннотация: The immunogenicity of the artificial protein albebetin and its derivatives with active peptide fragments was investigated. We also studied the influence of the peptides on the immunogenicity of the whole construct and contribution of each component to the immunogenicity. Two of three studied proteins contained active peptides from human IFN-alpha and insulin. Three continuous antigenic sites with different immunogenic potential were recognized in the chimerical proteins. The interferon fragment was the immunodominant site in the albeferon and albeferon-insulin molecules, while the insulin fragment displayed low immunogenic activity. All continuous B-epitopes are located at the boundaries of the secondary structure elements and at the predicted surface-located sites of albebetin molecule. Thus, peptide fragments attached to the artificial protein carrier can influence immunogenicity of the resulting construct.
- Добавил в систему: Долгих Дмитрий Александрович