Аннотация:Neuronal hyperexcitability is a well-known phenomenon in amyotrophic lateral
sclerosis and other neurodegenerative diseases. The use of transcranial magnetic
stimulation in clinical and research practice has recently made it possible to detect motor
cortex hyperexcitability under clinical conditions. Despite numerous studies, the
mechanisms and sequelae of the development of hyperexcitability still have not been
completely elucidated. In this chapter, we discuss the possibilities for detecting motor
cortex hyperexcitability in patients with amyotrophic lateral sclerosis using transcrani‐
al magnetic stimulation. The potential relationship between hyperexcitability and
neuronal degeneration or neuroplasticity processes is discussed using the data obtained
by navigated transcranial magnetic stimulation and neuroimaging data, as well as the
data of experimental studies.
Keywords: transcranial magnetic stimulation, amyotrophic lateral sclerosis, hyperex‐
citability, excitotoxicity, neuroplasticity