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Reduced susceptibility and resistance to bedaquiline in clinical M. tuberculosis isolatesстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Krylova L.Y., Antonova O.V., Kholina M.S., Kulagina E.V., Nosova E.Y., Safonova S.G., Borisov S.E., Zimenkov D.V.
- Журнал: Journal of Infection
- Том: 23
- Год издания: 2020
- Издательство: W. B. Saunders Co., Ltd.
- Местоположение издательства: United Kingdom
- DOI: 10.1016/j.jinf.2020.01.007
- Аннотация: Bedaquiline is an effective drug used to treat MDR and XDR tuberculosis, providing high cure rates in complex therapy. Mutations in the mmpR (rv0678) and atpE genes are associated with reduced susceptibility to bedaquiline and have been identified in both in vitro selected strains and clinical isolates. However, the phenotypic criteria used to detect bedaquiline resistance have yet to be established due to the collection of few clinical isolates from patients receiving bedaquiline-containing treatment regimens.
- Добавил в систему: Холина Маргарита Сергеевна