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PCSK-9: modern views about biological role and possibilities of use as a diagnostic marker for cardiovascular diseasesстатья Исследовательская статья
- Авторы: Chaulin A.M., Duplyakov D.V.
- Журнал: Kardiologiya: novosti, mneniya, obuchenie [Cardiology: News, Opinions, Training]
- Том: 7
- Номер: 4
- Год издания: 2019
- Первая страница: 24
- Последняя страница: 35
- DOI: 10.24411/2309-1908-2019-14004
- Аннотация: This part of our review is devoted to the discussion of the possibility of using proprotein convertase subtilisin/ Kexin type-9 (PCSK-9) as a biomarker for the detection of lipid metabolism disorders and atherosclerotic lesions, which are an integral part of cardiovascular diseases. PCSK-9 concentrations are associated (correlated) with metabolic parameters (total cholesterol, low-density lipoproteins, triglycerides, glucose, γ-gamma-glutamyltransferase), vascular changes, body mass index, age, sex. Levels of PCSK-9 depend on many factors: the method of determination (type of antibodies used in immunoassay), lipid-lowering therapy (statins, fibrates), comorbidities (renal failure, diabetes, hypothyroidism, obesity, inflammatory diseases), diet, gender, circadian, age-sex and race-population characteristics.
- Добавил в систему: Чаулин Алексей Михайлович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | pcsk-9-sovremenn-e-predstavleniya-o-biologicheskoy-roli-i-v… | 816,5 КБ | 29 февраля 2020 [ChaulinAM] |