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Carotid atherosclerosis progression in postmenopausal women receiving a mixed phytoestrogen regimen: Plausible parallels with Kronos early estrogen replacement studyстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 12 августа 2020 г.
- Авторы: Kirichenko T.V., Myasoedova V.A., Ravani A.L., Sobenin I.A., Orekhova V.A., Romanenko E.B., Poggio P., Wu W.K., Orekhov A.N.
- Журнал: Biology
- Том: 9
- Номер: 3
- Год издания: 2020
- Издательство: MDPI Publishing
- Местоположение издательства: Basel, Switzerland, Switzerland
- Первая страница: 48:1
- Последняя страница: 48:10
- DOI: 10.3390/biology9030048
- Аннотация: This randomized double-blinded, placebo-controlled clinical trial evaluated the progression of intima-media thickness of common carotid artery (cIMT) and the effect of phytoestrogen therapy on atherosclerosis development in early and late postmenopausal women. The 2-year cIMT progression was evaluated in 315 early postmenopausal women aged 40–55 years and in 231 late postmenopausal women aged 60–69 years free of cardiovascular disease. B-mode ultrasound was done at baseline and after 12 and 24 months of follow-up. The study revealed no significant changes in the rate of cIMT progression in 315 early postmenopausal women. By contrast, a statistically significant difference in the rate of atherosclerosis development was observed in late postmenopausal women treated with phytoestrogens compared to placebo (p = 0.008). The rate of cIMT progression in the placebo group was 0.019 mm/year led to a significant increase of cIMT during the observation period (p = 0.012), while the rate of cIMT progression in phytoestrogen late postmenopausal recipients was 0.011 mm/year, and total change did not reach statistical significance during the follow-up period (p = 0.101). These results suggest that late postmenopausal women can be a suitable cohort for trials assessing the anti-atherosclerosis effects of phytoestrogen preparations. In particular, the beneficial effect of phytoestrogens on cIMT progression was demonstrated in late postmenopausal women.
- Добавил в систему: Романенко Елена Борисовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Kirichenko20_Carotid_atherosclerosis.pdf | Kirichenko20_Carotid_atherosclerosis.pdf | 258,2 КБ | 19 марта 2020 [Romanenko_Elena] |