Synthesis of tritium-labelled biologically active analogues of progesterone by selective hydrogenation of 16 alpha,17 alpha-cyclohex-3 '-en-pregna-1,4-dien-3,20-dioneстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:The procedure of selective hydrogenation with gaseous tritium of 16 alpha,17 alpha-cyclohex-3'-en-pregna-1,4-dien-3,20-dione (St0) has been elaborated, and isotopically labelled 16 alpha,17 alpha-cyclohexanopregna-1,4-dien-3,20-dione (St1), 16 alpha,17 alpha-cyclohex-3'-en-pregn-4-en-3,20-dione (St2), 16 alpha,17 alpha-cyclohexanopregn-4-en-3,20-dione (St3) with molar radioactivity of 41, 44, 85 Ci/mmol, respectively, obtained. By hydrogenation with gaseous hydrogen, tritium labelled (St3) was converted to 16 alpha,17 alpha-cyclohexano-5 alpha-pregnan-3,20-dione (5 alpha-St4) and 16 alpha,17 alpha-cyclohexano-5 beta-pregnan-3,20-dione (5 beta-St4).