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Palmitic Acid Induces the Opening of a Ca2+-Dependent Pore in the Plasma Membrane of Red Blood Cells: The Possible Role of the Pore in Erythrocyte Lysisстатья
Информация о цитировании статьи получена из
Web of Science,
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 октября 2016 г.
- Авторы: Belosludtsev Konstantin N., Trudovishnikov Alexander S., Belosludtseva Natalia V., Agafonov Alexey V., Mironova Galina D.
- Журнал: Journal of Membrane Biology
- Том: 237
- Номер: 1
- Год издания: 2010
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 13
- Последняя страница: 19
- DOI: 10.1007/s00232-010-9302-1
- Аннотация: Earlier we found that in the presence of Ca2+ palmitic acid (Pal) increases the nonspecific permeability of artificial (planar and liposomal) membranes and causes permeabilization of the inner mitochondria' membrane. An assumption was made that the mechanism of Pal/Ca2+-induced membrane permeabilization relates to the Ca2+-induced phase separation of Pal and can be considered as formation of fast-tightening lipid pores due to chemotropic phase transition in the lipid bilayer. In this article, we continue studying this pore. We have found that Pal plus Ca2+ permeabilize the plasma membrane of red blood cells in a dose-dependent manner. The same picture has been revealed for stearic acid (20 mu M) but not for myristic and linoleic acids. The Pal-induced permeabilization of erythrocytic membranes can also occur in the presence of Ba2+ and Mn2+ (200 mu M), but other bivalent cations (200 mu M Mg2+, Sr2+, Ni2+, Co2+) are relatively ineffective. The formation of Pal/Ca2+-induced pores in the erythrocytic membranes has been found to result in the destruction of cells.
- Добавил в систему: Белослудцев Константин Николаевич