A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis

Dmitriev, S.E.; Vladimirov, D.O.; Lashkevich, K.A.

Авторы: Dmitriev S.E., Vladimirov D.O., Lashkevich K.A.
Журнал: Biochemistry (Moscow)
Том: 85
Номер: 11
Год издания: 2020
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 1389
Последняя страница: 1421
Оригинальные версии: Краткий справочник по низкомолекулярным ингибиторам эукариотической трансляции
DOI: 10.1134/S0006297920110097
Аннотация: Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor, antiviral, antiinflammatory, and antiparasitic therapies. Currently, a broad array of small-molecule drugs is known that specifically inhibit protein synthesis in eukaryotic cells. Many of them are well-studied ribosome-targeting antibiotics that block translocation, thepeptidyl transferase center or the polypeptide exit tunnel, modulate the binding of translation machinery components to theribosome, and induce miscoding, premature termination or stop codon readthrough. Such inhibitors are widely used as anticancer, anthelmintic and antifungal agents in medicine, as well as fungicides in agriculture. Chemicals that affect the accuracy of stop codon recognition are promising drugs for the nonsense suppression therapy of hereditary diseases and restoration of tumor suppressor function in cancer cells. Other compounds inhibit aminoacyl-tRNA synthetases, translation factors, and components of translation-associated signaling pathways, including mTOR kinase. Some of them haveantidepressant, immunosuppressive and geroprotective properties. Translation inhibitors are also used in research for gene expression analysis by ribosome profiling, as well as in cell culture techniques. In this article, we review well-studied and less known inhibitors of eukaryotic protein synthesis (with the exception of mitochondrial and plastid translation) classified by their targets and briefly describe the action mechanisms of these compounds. We also present a continuously updated database (http://eupsic.belozersky.msu.ru) that currently contains information on 370 inhibitors of eukaryotic protein synthesis.
Добавил в систему: Лашкевич Ксения Александровна

	ИСТИНА	Войти в систему Регистрация
	ФНКЦ РР
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ФНКЦ РР

A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesisстатья

Прикрепленные файлы