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Nanomechanical properties of Monilethrix affected hair are independent of phenotypeстатья
- Авторы: Breakspear Steven, Ivanov Dimitri A., Noecker Bernd, Popescu Crisan
- Журнал: Journal of Structural Biology
- Год издания: 2021
- Издательство: Academic Press
- Местоположение издательства: United States
- DOI: 10.1016/j.jsb.2020.107679
- Аннотация: Utilising the AFM nanoindentation technique for the study of hair cross- and longitudinal sections, the mechanical anisotropy of human hair fibres affected by a rare congenital condition, Monilethrix, has been investigated for the first time. Supported by X-ray microdiffraction data, and applying a model based on an ideal composite material consisting of rods (KIFs) and matrix (KAPs), to Monilethrix affected fibres it has been shown that the results could be grouped into clearly different classes, namely: almost isotropic behaviour for Monilethrix affected hairs and anisotropic behaviour for Control hair. Moreover, AFM nanoindentation of hair cross sections has demonstrated, also for the first time that hairs affected by Monilethrix have a continuous, and not periodic, weakness within the cortex. This has been attributed to disruptions in the KIF-KIF, KIF-intermacrofibrillar matrix or KIF-desmosome complexes within the hair shaft, as suggested by X-ray microdiffraction examination. Hairs from a patient exhibiting no obvious phenotype exhibited similar mechanical weakness despite the otherwise normal visual appearance of the fibre. This further supports a hypothesis that the beaded appearance of Monilethrix hair is a secondary factor, unrelated to the inherent structural weakness.
- Добавил в систему: Иванов Дмитрий Анатольевич