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The Effect of Ionizing Radiation on Cognitive Functions in Mouse Models of Alzheimer’s Diseaseстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 июля 2021 г.
- Авторы: Chicheva M.M., Mal’tsev A.V., Kokhan V.S., Bachurin S.O.
- Журнал: Doklady Biological Sciences
- Том: 494
- Номер: 1
- Год издания: 2020
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 225
- Последняя страница: 227
- DOI: 10.1134/s0012496620050026
- Аннотация: The present study demonstrates the effect of combined ionizing radiation (γ rays, 0.24 Gy, 661.7 keV, whole body and 12C, 0.18 Gy, 450 MeV, head region) on the behavior of animals in mouse transgenic models of Alzheimer’s disease. Significant improvement of spatial learning and stimulation of locomotor and exploratory behavior were observed in wild-type mice after irradiation. However, an anxiolytic effect and stimulation of locomotor and exploratory behavior were revealed in irradiated mice with tauopathy. Mice with cerebral amyloidosis also exhibited improved learning in the odor recognition test. No negative effects of irradiation were detected.
- Добавил в систему: Лозинская Наталья Александровна