Urokinase Receptor uPAR Overexpression in Mouse Brain Stimulates the Migration of Neurons into the Cortex during Embryogenesis

Shmakova, A.A.; Balatskiy, A.V.; Kulebyakina, M.A.; Schaub, T.; Karagyaur, M.N.; Kulebyakin, K.U.; Rysenkova, K.D.; Tarabykin, V.S.; Tkachuk, V.A.; Semina, E.V.

Авторы: Shmakova A.A., Balatskiy A.V., Kulebyakina M.A., Schaub T., Karagyaur M.N., Kulebyakin K.Uy, Rysenkova K.D., Tarabykin V.S., Tkachuk V.A., Semina E.V.
Журнал: Russian Journal of Developmental Biology
Том: 52
Номер: 1
Год издания: 2021
Издательство: Springer Verlag
Местоположение издательства: Germany
Первая страница: 53
Последняя страница: 63
DOI: 10.1134/S1062360421010069
Аннотация: The regulation of neuronal migration in the cerebral cortex during embryonic development is oneof the most important but underinvestigated processes that determines the correct formation of neural networksand the development of cognitive functions. Mutations of the urokinase receptor (uPAR) gene in micelead to spontaneous seizures; polymorphisms of the PLAUR gene encoding uPAR in humans are associatedwith autism spectrum disorders. The effect of uPAR overexpression on the radial migration of neurons in thecerebral cortex during mouse embryogenesis has been investigated. The number of neurons migrating fromthe ventricular zone of proliferating progenitors to the outer layers of the cerebral cortex was evaluated. Wefound that uPAR overexpression significantly stimulates radial neuronal migration to the outer layers of thedifferentiating cortex. These data show for the first time uPAR-dependent regulation of neuronal migrationin the embryonic period of the cerebral cortex development. Further study of uPAR’s role in regulating themigration trajectory of neuronal precursors will advance our understanding of the mechanisms of brain formationin health and disease.
Добавил в систему: Семина Екатерина Владимировна

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Urokinase Receptor uPAR Overexpression in Mouse Brain Stimulates the Migration of Neurons into the Cortex during Embryogenesisстатья

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