Bilayer aberration-inducing gel phantom for high intensity focused ultrasound applications

Peek, A.T.; Hunter, C.; Kreider, W.; Khokhlova, T.D.; Rosnitskiy, P.B.; Yuldashev, P.V.; Sapozhnikov, O.A.; Khokhlova, V.A.

Авторы: Peek A.T., Hunter C., Kreider W., Khokhlova T.D., Rosnitskiy P.B., Yuldashev P.V., Sapozhnikov O.A., Khokhlova V.A.
Журнал: Journal of the Acoustical Society of America
Том: 148
Номер: 6
Год издания: 2020
Издательство: Acoustical Society of America
Местоположение издательства: United States
Первая страница: 3569
Последняя страница: 3580
DOI: 10.1121/10.0002877
Аннотация: Aberrations induced by soft tissue inhomogeneities often complicate high-intensity focused ultrasound (HIFU) therapies. In this work, a bilayer phantom made from polyvinyl alcohol hydrogel and ballistic gel was built to mimic alternating layers of water-based and lipid tissues characteristic of an abdominal body wall and to reproducibly distort HIFU fields. The density, sound speed, and attenuation coefficient of each material were measured using a homogeneous gel layer. A surface with random topographical features was designed as an interface between gel layers using a 2D Fourier spectrum approach and replicating different spatial scales of tissue inhomogeneities. Distortion of the field of a 256-element 1.5 MHz HIFU array by the phantom was characterized through hydrophone measurements for linear and nonlinear beam focusing and compared to the corresponding distortion induced by anex vivo porcine body wall of the same thickness. Both spatial shift and widening of the focal lobe were observed, as well as dramatic reduction in focal pressures caused by aberrations. The results suggest that the phantom produced levels of aberration that are similar to a real body wall and can serve as a research tool for studying HIFU effects as well as for developing algorithms for aberration correction.
Добавил в систему: Хохлова Вера Александровна

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Bilayer aberration-inducing gel phantom for high intensity focused ultrasound applicationsстатья

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