Аннотация:The rapid integration of the post-Soviet Russia into the system of market relations predetermined, on the one hand, a tangible “shift to the sea” of industrial activity, infrastructure, and population, on the other, initiated further “stratification” of coastal zones on the level and pace of socio-economic dynamics. Important actors in transformation of the Russian interregional innovation space are the coastal zones being country's priority geo-economic corridors, and the clusters of residential and economic activity. The study deals with the external and internal determinants of economic growth of the leading maritime agglomerations of the European part of Russia with an emphasis on the role of the innovation factor. The elements of the third industrial revolution in the spatial structure of the leading maritime agglomerations and the resulting territorial, economic, technological, social and environmental effects are identified. The impact of innovations on the transformation of agglomeration spaces of coastal regions of the European part of Russia is assessed.