Dicarboxylate-substituted octacalcium phosphates for hydrogel filling and fabrication of resorbable ceramicsстатья
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Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
Аннотация:The main features of the synthesis of carboxylate-substituted analogs of octacalcium phosphateCa8(HPO4)2(PO4)4·5H2O (OCP) by hydrolysis of brushite (CaHPO4⋅2H2O) and tricalcium phosphateα-Са3(РО4)2 (α-TCP) in buffer solutions based on the salts of succinic, adipic, and citric acids are summarized.The synthesis of succinate-substituted (Suc@OCP) and adipate-substituted (Adi@OCP) OCPs givesthe powders with Ca8(HPO4)2 – xАx(PO4)4⋅zH2O (А = Suc, Аdi) composition. Thermolysis of substitutedOCPs results in a mixture of β-Са3(РО4)2 (β-TCP) and hydroxyapatite Са10(РО4)6(ОН)2 (HA). Thermolysisfeatures include the absence of an apatite-like decomposition product of pure OCP and higher decompositiontemperatures compared to the pure OCP. Suc@OCP and Adi@OCP powders were used for the filling ofhydrogels based on polyethylene glycol diacrylate (PEGDA) for the creation of a deformable compositeimplant by a stereolithographic 3D printing method and for fabrication of biphasic TCP/HAp ceramics.