Association of the EPAS1 Gene G/A Polymorphismwith Successful Performance in a Group of Russian Wrestlers

Bondareva, E.A.; Godina, E.Z.

Авторы: Bondareva E.A., Godina E.Z.
Журнал: Russian Journal of Genetics
Том: 6
Номер: 8
Год издания: 2016
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 793
Последняя страница: 797
DOI: 10.1134/S2079059716080049
Аннотация: Abstract—A large number of studies have shown that the EPAS1 gene may serve as a possible predictor of success in sports because of its influence on the processes of oxygen transportation and consumption. However, the data concerning the impact of EPAS1 polymorphisms on sports achievements in the contemporary research literature are very scarce and contradictory. The aim of the present paper is to study the genetic selection for the polymorphic system of the EPAS1 (rs1867785) gene in a group of male sambo practitioners. The study is carried out on 312 Russian males from 18 to 30 years of age, including 220 professional athletes and 92 non-athletes, who served as the control group. The genotype for a single-nucleotide G/A polymorphism of the EPAS1 gene is determined for each participant of the study. Analysis of the EPAS1 genotype frequencies revealed statistically significant differences between the two groups. The group of professional athletes exhibited an increase of the АА and AG genotype frequencies (χ2 = 8.68, p = 0.01). Thus, sambo wrestlers of high professional levels are characterized by having the minor А-allele of the EPAS1 gene in their genotypes. The odd ratio (OR) calculated for this group is 1.800 (95% CI 1.227–2.641), demonstrating that the carriers of the А-allele of the EPAS1 gene have some advantage over the carriers of the G-allele. OR for the highest ranked wrestlers is even higher, 1.990 (95% CI 1.195–3.313). These results suggest directed genetic selection in the А-allele carriers of the EPAS1 gene among sambo wrestlers. Keywords: EPAS1, polymorphism, hypoxia, sports selection, genetic selection, highly ranked professional athletes, sambo wrestlers
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Association of the EPAS1 Gene G/A Polymorphismwith Successful Performance in a Group of Russian Wrestlersстатья

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