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Joint Solubilization of Lipophilic Drug Amlodipine and Glyceryl Monolaurate in Aqueous Micellar Solutions of Tween 80статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 июля 2013 г.
- Авторы: Zadymova N.M., Ivanova N.I.
- Журнал: Moscow University Chemistry Bulletin
- Том: 68
- Номер: 2
- Год издания: 2013
- Издательство: Allerton Press Inc.
- Местоположение издательства: United States
- Первая страница: 110
- Последняя страница: 117
- DOI: 10.3103/S0027131413020090
- Аннотация: The solubilization of lipophilic amlodipine (Am is a antihypertensive drug) and nonionic surfactant glyceryl monolaurate (GML is a skin permeation enhancer), as well as their joint solubilization (co-solubilization) have been measured by UV-spectroscopy and refractometry in aqueous micellar solutions of Tween 80 (Tw). The properties of mixed micelles (Tw + GML, Tw + Am, Tw + GML + Am) have been studied, including the aggregation number of components, the localization of solubilizates, diffusion coefficients, the size and the degree of hydration. As a result of co-solubilization, (Tw + GML + Am) three-component micelles contain 4.2 times more molecules of the drug than (Tw + Am) two-component ones. The experimental data on the kinetics of mass transfer of Am by micelles based on Tw are in good agreement with the calculations under diffusion theory; furthermore, three-component micelles carry Am more effectively than two-component micelles.
- Добавил в систему: Задымова Наталья Михайловна