Dimerization energetics of DNA minor groove bindersстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 апреля 2017 г.
Авторы:
Kostjukov V.V. ,
Miloserdova Y.G. ,
Shram O.A. ,
Rubinson M.A. ,
Evstigneev M.P.
Журнал:
Ukrainian Journal of Physics
Том:
59
Номер:
5
Год издания:
2014
Издательство:
Naukova Dumka
Местоположение издательства:
Ukraine
Первая страница:
461
Последняя страница:
472
Аннотация:
The energy analysis of a dimerization in aqueous solutions of seven biologically active lexitropsins, which are different by structure, was carried out with the use of the molecular simulation method. The main stabilization of dimers was shown to take place owing to hydrophobic and intermolecular van der Waals interactions. The latter are mainly associated with energyfavorable contacts between the aromatic rings of molecules and their peptide groups. Despite the significant dipole moments of the molecules concerned, the electrostatic interactions are relatively weak and destabilize the complexes because of the unfavorable relative arrangement of molecular dipoles. Entropic factors and the dehydration were shown to also hinder the dimerization. © V.V. KOSTJUKOV, YU.G. MILOSERDOVA, O.A. SHRAM, M.A. RUBINSON, M.P. EVSTIGNEEV, 2014.
Добавил в систему:
Евстигнеев Максим Павлович