Аннотация:The interest in percutaneous high-tech cardiac procedures has increased in recent years together with its safety and effi- cacy. in fragile patients, procedural sedation and analgesia are used to perform most of the procedures. general anesthesia remains the technique of choice during the team learning curve and might be required in selected patients or in emergent situations. despite the high costs of percutaneous high-tech cardiac procedures, the decrease in length of hospital stays, rate of intensive care admission and complications, balance the increase in devices costs. in fragile patients who undergo percutaneous high tech cardiac procedures, the primary role of the anesthesiologist is to prevent the need for postpro- cedural intensive care unit and complications rate. Starting from the experience of a large university third level hospital we identified the eight most commonly performed contemporary percutaneous high tech cardiac procedures (ventricular tachycardia and atrial fibrillation ablation, protected percutaneous coronary intervention, transcatheter aortic valve im- plantation, MitraClip® (Abbott Laboratories; Abbott Park, IL, USA), percutaneous patent foramen ovale closure, left atrial appendage closure, and dysfunctional lead extraction), discuss the role of procedural sedation and analgesia in this setting, and explore future perspectives.(Cite this article as: Zangrillo a, Morselli F, lombardi g, yavorovskiy a, likhvantsev V, Beretta l, et al. Procedural seda- tion and analgesia for percutaneous high-tech cardiac procedures. Minerva Cardiol Angiol 2021;69:000-000. DOI: 10.23736/ S2724-5683.20.05211-1)Key words: Anesthesia; Intensive Care Units; Anesthesia, cardiac procedures; Cardiac surgical procedures.