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ANTIPROLIFERATIVE ACTIVITY OF THE CYCLIZATION PRODUCTS OF 1-(2-OXOCYCLOHEXYL)ETHANE-1,1,2,2-TETRACARBONITRILE AND alpha,beta-UNSATURATED ALDEHYDESстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 июня 2021 г.
- Авторы: Mar'yasov M.A., Davydova V.V., Nasakin O.E., Tafeenko V.A.
- Журнал: Pharmaceutical Chemistry Journal
- Том: 55
- Номер: 1
- Год издания: 2021
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 26
- Последняя страница: 29
- DOI: 10.1007/s11094-021-02367-3
- Аннотация: The antiproliferative activity of previously obtained 3-R-6-imino-2,7-dioxabicyclo[3.2.1.]octane-4,4,5-tricarbonitriles was tested on 59 cell lines obtained from human lung, colon, brain, ovary, kidney, prostate, and breast tumors and leukemia and melanoma. The most pronounced effect was observed against blood cancer cell lines of leukemia. The strength of the activity and specificity of the compounds on certain types of cells were related directly to the nature of the 3-substituent on the 2,7-dioxabicyclo[3.2.1]octane core. Compounds with multiple bonds and alkyl radicals exhibited more pronounced cytotoxic activity. A compound with a coumarin moiety showed high activity exceeding those of reference drugs (dacarbazine, cisplatin) with respect to kidney cancer cell lines.
- Добавил в систему: Тафеенко Виктор Александрович