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DLP printing of hydrogel/calcium phosphate composites for the treatment of bone defectsстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 22 декабря 2021 г.
- Авторы: Preobrazhenskiy I.I., Tikhonov A.A., Evdokimov P.V., Shibaev A.V., Putlyaev V.I.
- Журнал: Open Ceramics
- Том: 6
- Год издания: 2021
- Издательство: Elsevier Ltd
- Местоположение издательства: London
- Первая страница: 100115
- Номер статьи: 100115
- DOI: 10.1016/j.oceram.2021.100115
- Аннотация: In this work, biocomposites based on hydrogels filled with calcium phosphates were fabricated using DLP methodof 3D printing for the treatment of bone defects. The possibility to tune the functional properties of hydrogels suchas degradation, swelling, and mechanical behavior by using a mixture of monomers with different functionalityand different calcium phosphates was shown. Mechanical properties, photopolymerization, swelling behavior,and microstructure of hydrogels based on a mixture of poly(ethylene glycol) methacrylate/poly(ethylene glycol)diacrylate (PEGMA/PEGDA) monomers with different composition were studied. It was found that the usage ofα-tricalcium phosphate (α-TCP) powder as a filler for hydrogels allowed to increase the filler fraction up to 60 wt% in comparison with octacalcium phosphate (OCP) and brushite (10 wt%) without significant thickening ofphotosuspension for DLP printing. Finally, the main parameters of DLP printing for biocomposites based onPEGMA/PEGDA hydrogels were found, and the macroporous biocomposite filled with 60 wt% α-TCP with gyroidstructure was obtained. This study was partially supported by the RSF (grant #19-19-00587). Equipment was purchased using the funding of the Development Program of the Moscow State University.
- Добавил в систему: Преображенский Илья Иванович