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SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourseстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Konings Frank, Perkins Mark D., Kuhn Jens H., Pallen Mark J., Alm Erik J., Archer Brett N., Barakat Amal, Bedford Trevor, Bhiman Jinal N., Caly Leon, Carter Lisa L., Cullinane Anne, de Oliveira Tulio, Druce Julian, El Masry Ihab, Evans Roger, Gao George F., Gorbalenya Alexander E., Hamblion Esther, Herring Belinda L., Hodcroft Emma, Holmes Edward C., Kakkar Manish, Khare Shagun, Koopmans Marion P.G., Korber Bette, Leite Juliana, MacCannell Duncan, Marklewitz Marco, Maurer-Stroh Sebastian, Rico Jairo Andres Mendez, Munster Vincent J., Neher Richard, Munnink Bas Oude, Pavlin Boris I., Peiris Malik, Poon Leo, Pybus Oliver, Rambaut Andrew, Resende Paola, Subissi Lorenzo, Thiel Volker, Tong Suxiang, van der Werf Sylvie, von Gottberg Anne, Ziebuhr John, Van Kerkhove Maria D.
- Журнал: NATURE MICROBIOLOGY
- Год издания: 2021
- DOI: 10.1038/s41564-021-00932-w
- Аннотация: A group convened and led by the Virus Evolution Working Group of the World Health Organization reports on its deliberations and announces a naming scheme that will enable clear communication about SARS-CoV-2 variants of interest and concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has a linear, unsegmented, positive-sense RNA genome. As with all viruses, SARS-CoV-2 continuously adapts to changing environments in real time via random genome mutations that are subject to natural selection. Most mutations are neutral or detrimental to the virus; however, a small number of mutations may provide a selective advantage, such as escape from the host immune system or resistance to antiviral drugs. Such mutations may also lead to increased fitness for transmissibility. As mutated forms of viruses or variants spread from person to person, they will eventually be detected at the population level. The World Health Organization (WHO) COVID-19 Reference Laboratory Network has been tracking SARS-CoV-2 mutations since the beginning of the pandemic. In June 2020, the WHO Virus Evolution Working Group was established with a specific focus on SARS-CoV-2 variants, their phenotype and their impact on countermeasures. The WHO has developed a global risk-monitoring framework to coordinate components of an international system for monitoring and assessing SARS-CoV-2 variants and their impact. Specifically, this framework aims to collect, analyse and share data to identify crucial priorities, set triggers for decision making and enable and improve the capacities of laboratories, technical networks and expert groups. The WHO has provided working definitions of variants of interest (VOIs) and variants of concern (VOCs) that will be updated when required. These working definitions also consider changes that lead to an altered phenotype, which are harder to reflect in genotype-based classifications. Additionally, the WHO has advised how VOIs and VOCs should be reported to both national health authorities and to the organization itself. Initial cases or clusters associated with a VOC infection should be reported to the WHO through the International Health Regulations (2005) mechanism. The WHO has outlined actions required by its member states, reference laboratories and the WHO secretariat to assess the impact of VOIs and VOCs on the epidemiology and severity of COVID-19, and on the performance of available diagnostics, therapeutics, vaccines and public health initiatives. At the time of writing, several VOIs and VOCs are being tracked.
- Добавил в систему: Фенюк Борис Александрович