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Effects of ischemic and hypoxic preconditioning on the state of mitochondria and function of ischemic kidneysстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Kirpatovskii V.I., Kazachenko A.V., Plotnikov E.Y., Kon’kova T.A., Drozhzheva V.V., Zorov D.B.
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 143
- Номер: 1
- Год издания: 2007
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 105
- Последняя страница: 109
- Аннотация: Laser confocal. microscopy showed that fluorescence of tetramethylrhodamine ethyl ether probe specifically accumulating in energized mitochondria significantly decreased in renal tubular epithelium after 40-min thermal ischemia, while fluorescence of dichlorodihydrofluorescein and diarninofluorescein probes in the same structures increased under these conditions, which attests to increased generation of ROS and NO, respectively. These forms were generated predominantly in mitochondria of tubular epitheliocytes. Hypoxic preconditioning (a series of sessions of breathing hypoxic mixture) preserved functional activity of mitochondria and prevented activation of ROS and NO generation. Ischemic preconditioning of the kidney consisting of three preliminary episodes of vascular clamping (5 min with 5 min reperfusion periods) also increased the percentage of functionally active mitochondria and prevented activation of NO synthesis without appreciably modifying ROS production. Both protective methods significantly reduced the severity of postischemic dysfunction of the kidney.
- Добавил в систему: Плотников Егор Юрьевич