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INTERHEMISPHERIC FUNCTIONAL DISCONNECTION IN AGING: INFLUENCE OF GENDER AND CLUSTRIN GENOTYPEтезисы доклада
- Авторы: Ponomareva N.V., Andreeva T.V., Protasova M., Kunizheva S.S., Shagam L.I., Malina D.D., Goltsov A., Fokin V.F., Rogaev E.I.
- Сборник: "COGNITIVE SCIENCES, GENOMICS AND BIOINFORMATICS" (CSGB-2016)
- Тезисы
- Год издания: 2016
- Место издания: Novosibirsk
- Первая страница: 48
- Последняя страница: 48
- Аннотация: Motivation and Aim: Genetic predisposition and aging are the greatest known risk factors for Alzheimer’s disease (AD). Clusterin (CLU) gene was identified to be associated with AD in different populations, including Russian population (Harold et al., 2009; Lambert et al., 2009; Golenkina et al., 2010). The prevalence of AD is higher in women, but the mechanisms of the gender-related differences are not completely understood. The normal brain undergoes a substantial decrease of functional connections within resting-state networks during aging, but gender- and CLU-related differences in functional connectivity remain unknown. The present study aimed to determine the possible gender-related differences of the alterations of brain functional connectivity in normal aging and to define the effect of CLU genotype on theses alterations. Methods and Algorithms: We examined age-related differences in resting state functional connectivity assessed by interhemispheric EEG coherence in 157 non-demented volunteers (age range 20-80 years), subdivided into subgroups of those younger and older than 50 years of age and stratified by gender and CLU rs11136000 genotype. Informed written consent was obtained from all participants. All subjects underwent a neurological examination and cognitive screening. The significance of the differences between the logtransformed EEG and parameters in different groups was estimated using ANOVA in the general linear model (GLM). The analysis was adjusted for ApoE genotype. Results: The older women showed decreased interhemispheric coherence values compared to the younger women, while in the man age-dependent decrease of the EEG coherence was significant only for beta coherence. In the women older than 50 years of age the presence of AD risk variant CLU CC was associated with lower alpha1 coherence. The reduction of alpha and beta interhemispheric coherence correlated with the worse performance in Luria verbal memory test. Conclusion: The results indicate that altered functional connectivity in normal aging is associated with gender and CLU genotype. Progressive decline in interhemispheric connectivity contributes to memory decrement and suggests the impact of age-related disconnection process in pathogenesis of AD in women carrying AD risk variant CLU CC. The results suggest that the neurophysiological markers may be important in monitoring preclinical disease progression in at-risk elderly
- Добавил в систему: Фокин Виталий Федорович