EXISTENCE AND DYNAMICS OF STRAINS IN A NONLOCAL REACTION-DIFFUSION MODEL OF VIRAL EVOLUTIONстатья
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Дата последнего поиска статьи во внешних источниках: 30 июня 2021 г.
Аннотация:In this work, we develop a mathematical framework for predicting and quantifying virus diversity evolution during infection of a host organism. It is specied as a virus density distribution with respect to genotype and time governed by a reaction-diusion integro-dierential equationtaking virus mutations, replication, and elimination by immune cells and medical treatment into account. Conditions for the existence of virus strains that correspond to localized density distributions in the space of genotypes are determined. It is shown that common viral evolutionary traits like diversication and extinction are driven by nonlocal interactions via immune responses, target-cell competition, and therapy. This provides us with a mechanistic explanation for clinically relevant properties like immune escape and drug resistance selection, and allows us to link virus genotypes tophenotypes.