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A convenient catalytic silicon-assisted route towards new non-proteinogenic amino acids with methylenebisphosphonic acids moietiesстатья Исследовательская статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 октября 2021 г.
- Авторы: Prishchenko Andrey A., Alekseyev Roman S., Livantsov Mikhail V., Novikova Olga P., Livantsova Ludmila I., Petrosyan Valery S.
- Журнал: Journal of Organometallic Chemistry
- Том: 949
- Год издания: 2021
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Номер статьи: 121950
- DOI: 10.1016/j.jorganchem.2021.121950
- Аннотация: The new non-proteinogenic amino acids with methylenebisphosphonic acids moieties are synthesized for the first time via unique reaction of tris(trimethylsilyl) phosphite and various N-formyl amino acids at the presence of effective catalyst – trimethylsilyl triflate under mild conditions. The further treatment of initially formed trimethylsilyl intermediates with the methanol excess resulted in the water-soluble non-proteinogenic amino acids with methylenebisphosphonic acids moieties in high yields. The catalytic scheme of target substances formation is proposed and discussed in detail. The structures of target functionalized amino acids and their precursors were confirmed by the 1H, 13C, 31P NMR spectra and high resolution mass spectra. The resulted compounds are of great interest as promising antiviral substances and effective ligands.
- Добавил в систему: Алексеев Роман Сергеевич