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Efficacy of (R)-6-Adamantane- Derivatives of 1,3-Oxazinan-2-One and Piperidine-2,4-Dione in The Treatment of Mice Infected by the A/California/04/2009 influenza Virusстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 ноября 2021 г.
- Авторы: Glubokova E.A., Leneva I.A., Kartashova N.P., Falynskova I.N., Tikhov R.M., Kuznetsov N.Yu
- Журнал: Acta Naturae (англоязычная версия)
- Том: 13
- Номер: 2
- Год издания: 2021
- Издательство: Park Media Ltd
- Местоположение издательства: Moscow, Russia (Federation)
- Первая страница: 116
- Последняя страница: 125
- Номер статьи: 49
- DOI: 10.32607/actanaturae.11020
- Аннотация: The World Health Organization (WHO) recommends antivirals as an additional line of defenseagainst influenza. One of such drugs is rimantadine. However, most of the circulating strains of influenza Aviruses are resistant to this drug. Thus, a search for analogs effective against rimantadine-resistant viruses isof the utmost importance. Here, we examined the efficiency of two adamantane azaheterocyclic rimantadinederivatives on a mouse model of pneumonia caused by the rimantadine-resistant influenza A virus /California/04/2009 (H1N1). BALB/c mice inoculated with the virus were treated with two doses (15 mg and 20 mg/kga day) of tested analogs via oral administration for 5 days starting 4 hours before the infection. The efficacywas assessed by survival rate, mean day to death, weight loss, and viral titer in the lungs. Oral treatment withboth compounds in both doses protected 60–100% of the animals, significantly increased the survival rate, andabolished weight loss. The treatments also inhibited virus titer in the lungs in comparison to the control group.This treatment was more effective compared to rimantadine at the same scheme and dosage. Moreover, the studyof the sensitivity of the virus isolated from the lungs of the treated mice and grown in MDCK cells showed thatno resistance had emerged during the 5 days of treatment with both compounds.
- Добавил в систему: Кузнецов Николай Юрьевич
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